The EU intends not to renew the registration of enylmorpholine

2024 01/05

Recently, the European Union issued a draft regulation on the non-renewal of the approval of the active substance enoyl morpholine. The Regulation does not renew the registration of the active substance enoylmorpholine in accordance with (EC) No 1107/2009. Eu Member States will withdraw authorisation for plant protection products containing enylmorpholine as an active substance. The main reason for not renewing the approval is that the European Food Safety Authority (EFSA) considers enylmorpholine to be an endocrine disruptor and reproductive toxicity Class 1B compound.

The comment period on the draft regulation is until February 13, 2024. At present, the date of approval of the EU registration authorization to revoke the registration of enoyl morpholine has not been determined, according to relevant EU regulations, after the registration of enoyl morpholine takes effect, EU member states must withdraw the registration authorization of pesticides containing enoyl morpholine within 6 months, and the grace period for the use of existing pesticide products in stock shall not exceed 12 months. The EU may further reduce the maximum residue limits (MRLs) for phenomorph in agricultural products.

dimethomorph; Dimethomorph; CAS login number: 110488-70-5; Current EU ratification expiration date: February 15, 2025; The structural formula is:



Enyl morph is a derivative of cinnamic acid, which is used to control plant diseases such as downy mildew and late blight on cruciferous vegetables, melons and fruit trees.

In October 2007, it was first approved under the old EU Regulation on Plant Protection Products (Directive 91/414/EEC) and subsequently included in the list of approved active substances under Regulation (EU) No 540/2011.

On May 26, 2023, the European Food Safety Authority (EFSA) issued the results of the peer review of enylmoline, which was the main reason for the ban of the substance because it belongs to the reproductive toxicity Class 1B substance, which may harm reproductive ability, and was judged to meet the endocrine disruptor standards for humans and wild mammals.